Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility
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چکیده
منابع مشابه
Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility.
Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractility of rat bladder were compared in vitro. Schild plot analysis of cumulative carbachol dose-response curves in the presence of antagonists was consistent with M3-mediated bladder contractions. However, nerve-evoked contractions were inhibited 15% at 30 Hz ( P < 0.01) by 10 nM pirenzepi...
متن کاملHeterogeneity of release-regulating muscarinic receptors in rat sympathetic neurons: evidence for inhibitory presynaptic M1 receptors
Of the 5 known subtypes of mAChRs, M2, M3, and M4 have been reported to act as inhibitory presynaptic receptors in the nervous system, in general, and in sympathetic neurons, in particular. M1 receptors, in contrast, have rather been viewed as facilitatory presynaptic receptors. In superior cervical ganglion (SCG) neurons, M1 receptors are well known to inhibit KCNQ channels. Previously, we wer...
متن کاملM2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder.
Normal rat bladder contractions are mediated by the M(3) muscarinic receptor subtype. The M(2) receptor subtype mediates contractions of the denervated, hypertrophied bladder. This study determined signal transduction mechanisms mediating contraction of the denervated rat bladder. Denervated bladder muscle strips were exposed to inhibitors of enzymes thought to be involved in signal transductio...
متن کاملM2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder.
The muscarinic receptor subtype-activated signal transduction mechanisms mediating rat urinary bladder contraction are incompletely understood. M(3) mediates normal rat bladder contractions; however, the M(2) receptor subtype has a more dominant role in contractions of the hypertrophied bladder. Normal bladder muscle strips were exposed to inhibitors of enzymes thought to be involved in signal ...
متن کاملAtropine resistance and muscarinic receptors in the rat urinary bladder.
The action of an anticholinesterase and an antimuscarinic drug upon nerve-induced contractions of the rat urinary bladder were examined during transmural stimulation at 20 Hz. Responses were graded in magnitude by limiting the duration of the stimulus trains. 2 Responses of low magnitude produced by short stimulus trains were unchanged by atropine; however, maximal responses resulting from long...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 1998
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.1998.274.2.r517